May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
Categories
Primary Antibodies
Cellular Localization
Cell Projection, Cytoplasm, cytoskeleton
Clonality
polyclonal
Description
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
Host
Rabbit
Immunogen
abl interactor 2
Isotype
IgG
Molecular Weight
56 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cell projection, Cytoplasm, Cytoskeleton
Synonyms
ABI2 Synonyms Abelson interactor 2, ABI 2, ABI2, ABI2B, Abl binding protein 3, abl interactor 2, AblBP3, AIP 1, Arg binding protein 1, ArgBP1, argBPIA, argBPIB, SSH3BP2
Antigen
ABI2
Uniprot
Q9NYB9
Gene Id
10152
Research Area
Signal Transduction
Weight
56kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)