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Home / Primary Antibodies / IHC Antibodies

PMAIP1 Antibody

SKU : BHA10559592

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA969433
Alternative Names	APR; NOXA
Categories	Primary Antibodies
Clonality	polyclonal
Description	Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 By similarity. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Host	Rabbit
Immunogen	Full length fusion protein
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1?By similarity. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.?
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PMAIP1 protein.
Subcellular Location	Mitochondrion

Uniprot	Q13794
Database Links	HGNC:9108 OMIM:604959 KEGG:hsa:5366 STRING:9606.ENSP00000326119 UniGene:Hs.96
Function	Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Pathway	p53 signaling pathway Apoptosis
Protein Families	PMAIP1 family
Tissue Specificity	Highly expressed in adult T-cell leukemia cell line.

Buffer	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Form	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Format	liquid
Purification	Antigen Affinity Purified
Purity	Antigen Affinity Purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559592	CSB-PA969433	100ul	$297		Add to Cart

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