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Home / Primary Antibodies / IHC Antibodies

Phospho-MAPK8IP1 (T103) Antibody

BHA10539213
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
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Uniprot Q9UQF2
Database Links

HGNC:6882

OMIM:125853

KEGG:hsa:9479

STRING:9606.ENSP00000241014

UniGene:Hs.234249
Function The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
Pathway MAPK signaling pathway
Protein Families JIP scaffold family
Tissue Specificity Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine. Decreased levels in pancreatic beta cells sensitize
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, IHC, IF, ELISA
Description WB ; IHC ; IF ; ELISA, WB ; ELISA ; IHC ; IF
Dilution

WB1:500-1:2000
IHC1:100-1:300
IF1:200-1:1000
ELISA1/5000
Tested Application WB,IHC,IF,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000
Datasheet
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10539213 CSB-PA080012 100ug $167
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BHA10539213 CSB-PA080012 50ug $100
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