Phospho-Lamin A/C (Ser301) Antibody

Mfr.No.	AF7177
Alternative Names	70 kDa lamin ; Cardiomyopathy dilated 1A (autosomal dominant) ; CDCD1 ; CDDC ; CMD1A ; CMT2B1 ; EMD2 ; FPL ; FPLD ; FPLD2 ; HGPS ; IDC ; Lamin A ; Lamin A/C ; Lamin A/C like 1 ; Lamin ; Lamin C ; Lamin-A/C ; LDP1 ; LFP ; LGMD1B ; Limb girdle muscular dystrophy 1B (autosomal dominant) ; LMN 1 ; LMN A ; LMN C ; LMN1 ; LMNA ; LMNA_HUMAN ; LMNC ; LMNL1 ; Prelamin A/C ; PRO1 ; Renal carcinoma antigen NY REN 32 ; Renal carcinoma antigen NY-REN-32 ; Renal carcinoma antigen NYREN32 ;
Antigen	Phospho-Lamin A/C (Ser301)
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Immunogen	A synthesized peptide derived from human Lamin A/C around the phosphorylation site of Ser301.
Molecular Weight	Observed Mol.Wt.: 74,65kDa. Predicted Mol.Wt.: 75kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-Lamin A/C (Ser301) Antibody detects endogenous levels of Lamin A/C only when phosphorylated at Ser301.
Subcellular Location	Nucleus. Nucleus envelope. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.

Uniprot

P02545

Gene Id

4000

Sequence

10 20 30 40 50
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR
60 70 80 90 100
SLETENAGLR LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA
110 120 130 140 150
RLQLELSKVR EEFKELKARN TKKEGDLIAA QARLKDLEAL LNSKEAALST
160 170 180 190 200
ALSEKRTLEG ELHDLRGQVA KLEAALGEAK KQLQDEMLRR VDAENRLQTM
210 220 230 240 250
KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR LADALQELRA
260 270 280 290 300
QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
310 320 330 340 350
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA
360 370 380 390 400
RMQQQLDEYQ ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG
410 420 430 440 450
RASSHSSQTQ GGGSVTKKRK LESTESRSSF SQHARTSGRV AVEEVDEEGK
460 470 480 490 500
FVRLRNKSNE DQSMGNWQIK RQNGDDPLLT YRFPPKFTLK AGQVVTIWAA
510 520 530 540 550
GAGATHSPPT DLVWKAQNTW GCGNSLRTAL INSTGEEVAM RKLVRSVTVV
560 570 580 590 600
EDDEDEDGDD LLHHHHGSHC SSSGDPAEYN LRSRTVLCGT CGQPADKASA
610 620 630 640 650
SGSGAQVGGP ISSGSSASSV TVTRSYRSVG GSGGGSFGDN LVTRSYLLGN
660
SSPRTQSPQN CSIM

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Applications	ELISA, WB
Dilution	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Manual
MSDS
Sample Preparation For Western Blotting.
Western Blotting Handbook.

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SKU	Supplier No.	Size	Your price	Quantity
BHA12910582	AF7177	100ul	$350		Add to Cart
BHA12910582	AF7177	200ul	$450		Add to Cart