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Home / Primary Antibodies / IHC Antibodies

Phospho-ILK (Ser246) Antibody

SKU : BHA10560187

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA059405
Alternative Names	ILK1; p59ILK; kinase ILK;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.Hannigan G.E., Nature 379:91-96(1996).Janji B., Oncogene 19:3069-3077(2000).Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 246(I-F-S(p)-H-P) derived from Human ILK.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. Hannigan G.E., Nature 379:91-96(1996). Janji B., Oncogene 19:3069-3077(2000). Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of ILK only when phosphorylated at serine 246.
Subcellular Location	Cell junction, focal adhesion, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, lamellipodium, Cytoplasm, myofibril, sarcomere

Uniprot	Q13418
Database Links	HGNC:6040 OMIM:602366 KEGG:hsa:3611 STRING:9606.ENSP00000299421 UniGene:Hs.706355
Function	Receptor-proximal protein kinase regulating integrin-mediated signal transduction
Pathway	PPAR signaling pathway Focal adhesion
Protein Families	Protein kinase superfamily, TKL Ser/Thr protein kinase family
Tissue Specificity	Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560187	CSB-PA059405	100ul	$360		Add to Cart

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