Phospho-GRB10 (Ser476) Antibody

Mfr.No.	AF2347
Alternative Names	grb 10 ; GRB IR ; grb-10 ; GRB10 adapter protein ; GRB10 adaptor protein ; GRB10 ; GRB10_HUMAN ; GRBIR ; Growth factor receptor bound protein 10 ; Growth factor receptor-bound protein 10 ; Insulin receptor binding protein ; Insulin receptor binding protein GRB IR ; Insulin receptor-binding protein Grb-IR ; IRBP ; KIAA0207 ; Maternally expressed gene 1 ; MEG1 ; RSS ;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Immunogen	A synthesized peptide derived from human GRB10 around the phosphorylation site of Ser476.
Molecular Weight	Observed Mol.Wt.: 80kDa. Predicted Mol.Wt.: 68kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-GRB10 (Ser476) Antibody detects endogenous levels of GRB10.
Subcellular Location	Cytoplasm. When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment.

Uniprot

Q13322

Gene Id

2887

Sequence

10 20 30 40 50
MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV
60 70 80 90 100
DLEALVNDMN ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ
110 120 130 140 150
PQVSPRQRVQ RSQPVHILAV RRLQEEDQQF RTSSLPAIPN PFPELCGPGS
160 170 180 190 200
PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK VVEILADMTA RDLCQLLVYK
210 220 230 240 250
SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE SKFLFRKNYA
260 270 280 290 300
KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK
310 320 330 340 350
ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG
360 370 380 390 400
RKQYNAPTDH GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG
410 420 430 440 450
MLLYQNYRIP QQRKALLSPF STPVRSVSEN SLVAMDFSGQ TGRVIENPAE
460 470 480 490 500
AQSAALEEGH AWRKRSTRMN ILGSQSPLHP STLSTVIHRT QHWFHGRISR
510 520 530 540 550
EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK NFQILPCEDD
560 570 580 590
GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.