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Home / Primary Antibodies / IHC Antibodies

Phospho-ATF2 (Ser472) Antibody

BHA10560217
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+1 866.986.9598
Email
[email protected]
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Uniprot P15336
Gene Id 1386
Database Links

HGNC:784

OMIM:123811

KEGG:hsa:1386

STRING:9606.ENSP00000264110

UniGene:Hs.592510
Function Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
Pathway Estrogen signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway TNF signaling pathway Th17 cell differentiation Thyroid hormone synthesis cGMP-PKG signaling pathway Glucagon signaling pathway
Protein Families BZIP family, ATF subfamily
Tissue Specificity Ubiquitously expressed, with more abundant expression in the brain.
Weight 54537 MW
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format liquid
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Applications ELISA, IHC
Description ELISA ; IHC, IHC ; ELISA
Dilution

IHC1:50-1:100
Tested Application ELISA,IHC;IHC:1:50-1:100
Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol
SKU Supplier No. Size Your price Quantity
BHA10560217 CSB-PA590863 100ul $360
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