PA-8

Mfr.No.	T41005
Description	PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo.
Molecular Formula	C17H18N4O4
Signaling Pathways	GPCR/G Protein
Smiles	COC1=CC(=CC=C1OCC=C)C1CC(=O)NC2=C1C(=O)NC(N)=N2
Cas Number	878437-15-1
Molecular Weight	342.35
Target	PACAP

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SKU	Supplier No.	Size	Your price
BHB20428813	T41005	1 mL	$43	Add to Cart
BHB20428813	T41005	5 mg	$39	Add to Cart
BHB20428813	T41005	10 mg	$72	Add to Cart
BHB20428813	T41005	25 mg	$155	Add to Cart
BHB20428813	T41005	50 mg	$272	Add to Cart
BHB20428813	T41005	100 mg	$478	Add to Cart