NLRP3/AIM2-IN-3

Mfr.No.	T60442
Description	NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 u M. NLRP3/AIM2-IN-3 is a potent inhibitor of NLRP3 and AIM2 inflammasome-dependent cell lysis with an IC50 value for cell lysis of 0.077 ± 0.008 u M. NLRP3/AIM2-IN-3 inhibits LPS/nigericin NLRP3/AIM2-IN-3 inhibits LPS/nigericin-stimulated cell lysis in THP-1 macrophages with an IC50 value of 0.077 ± 0.008 uM. NLRP3/AIM2-IN-3 interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC, inhibiting oligomerization of ASC.
Molecular Formula	C16H14N2O2
Signaling Pathways	Immunology/Inflammation, NF-kappab
Smiles	C(C(NC1=CC(O)=CC=C1)=O)C=2C=C3C(=CC2)C=CN3
Cas Number	1787787-60-3
Molecular Weight	266.29
Target	NOD, AIM2

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SKU	Supplier No.	Size	Your price
BHB20430451	T60442	1 mL	$75	Add to Cart
BHB20430451	T60442	5 mg	$68	Add to Cart
BHB20430451	T60442	10 mg	$109	Add to Cart
BHB20430451	T60442	25 mg	$228	Add to Cart
BHB20430451	T60442	50 mg	$372	Add to Cart
BHB20430451	T60442	100 mg	$597	Add to Cart
BHB20430451	T60442	500 mg	$1260	Add to Cart