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Home / Primary Antibodies / IHC Antibodies

NCF1 Antibody

SKU : BHA10557157

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA015525KA01HU
Alternative Names	NCF1;FLJ79451;NCF1A;NOXO2;SH3PXD1A;p47phox
Categories	Primary Antibodies, Primary Antibodies
Description	The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558. Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease. Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure.
Hgnc	7660
Host	Rabbit
Immunogen	Recombinant protein of human NCF1
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease	Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive (CGD1)
Isotype	IgG
Mgi	97283
Raised In	Rabbit, Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558. Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease. Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Cytoplasm, cytosol, Membrane, Peripheral membrane protein, Cytoplasmic side

Uniprot	P14598
Database Links	HGNC:7660 OMIM:233700 KEGG:hsa:653361 STRING:9606.ENSP00000289473 UniGene:Hs.647047
Function	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Pathway	Chemokine signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Osteoclast differentiation, Chemokine signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Osteoclast differentiation
Tissue Specificity	Detected in peripheral blood monocytes and neutrophils (at protein level).

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200, ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557157	CSB-PA015525KA01HU	100μl	$387.33		Add to Cart

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