Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that in humans is best known for its role in enabling female mammals to produce milk; however, it is influential over a large number of functions with over 300 separate actions of PRL having been reported in various vertebrates.[1] Prolactin is secreted from the pituitary gland in response to eating, mating, estrogen treatment, ovulation, and nursing. Prolactin is secreted in a pulsatile fashion in between these events. Prolactin also plays an essential role in metabolism, regulation of the immune system, and pancreatic development.
Function
Fertility & Pregnancy
Isotype
IgG1
Shape
Liquid
Specificity
human Prolactin
Research Area
Fertility & Hormones
Form
Liquid
Purity
Protein G affinity chromat ography, >95%
Storage Condition
Aliquot and store at -20 or -80 deg C. Avoid repeated freeze/thaw cycles
Applications
ELISA, CLIA
Tested Application
ELISA, CLIA
Reference
[1] Hair WM, Gubbay O, Jabbour HN, Lincoln GA. Prolactin receptor expression in human testis and accessory tissues: localization and functionMol. Hum. Reprod.,2002,8 (7): 606–11.
[2] Cooke N.E., Coit D., Shine J., Baxter J.D., Martial J.A. Human prolactin. cDNA structural analysis and evolutionary comparisons.J. Biol. Chem.1980, 256:4007-4016.
[3] Truong A.T., Duez C., Belayew A., Renard A., Pictet R.L., Bell G.I., Martial J.A.Isolation and characterization of the human prolactin gene.EMBO J.1983, 3:429-437.
[4] Hiraoka Y., Tatsumi K., Shiozawa M., Aiso S., Fukasawa T., Yasuda K., Miyai K.A placenta-specific 5'non-coding exon of human prolactin.Mol. Cell. Endocrinol. 1990,75:71-80.
Reviews of Mouse anti-human Prolactin(PRL) monoclonal Antibody