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Home / Primary Antibodies / Monoclonal Antibodies

WTAP antibody

SKU : BHA10809503

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Mfr.No.	FNab09530
Alternative Names	DKFZp686F20131 ; Femalelethal(2)Dhomolog ; hFL(2)D ; KIAA0105 ; WT1associatedprotein ; WTAP
Background	Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).
Categories	Primary Antibodies
Cellular Localization	Nucleus
Clonality	monoclonal
Description	Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
Host	Mouse
Immunogen	Wilms tumor 1 associated protein
Isotype	IgG1
Molecular Weight	49 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Nucleus
Synonyms	DKFZp686F20131, Female lethal(2)D homolog, hFL(2)D, KIAA0105, WT1 associated protein, WTAP

Uniprot	Q15007
Gene Id	9589
Clone No	9D4
Research Area	Epigenetics
Weight	49kDa

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:1000-1:10000
IF	1:20-1:200
IHC	1:20-1:200

Tested Application

WB: 1:1000-1:10000; IHC: 1:50-1:500

Manual	FNab09530.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809503	FNab09530	100ug	$300		Add to Cart

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