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Home / Primary Antibodies / Monoclonal Antibodies

Versican Antibody, Clone S351-23 - SMC-439

BHA11904248
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Contact us to order
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+1 866.986.9598
Email
[email protected]
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Swissprot Q62059
Accession Number AAH96495
Gene Id 13003
Target Versican
Clone No S351-23
Research Area Cell Signaling, Scaffold Proteins, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a Lectinlike sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length anddegree of modification by glycoaminoglycan chains. Accumulation around smooth muscle cells in lesions of athero-sclerosis suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels.
Shipping Temperature Blue Ice or 4°C
Specificity Detects >350kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications WB, ICC/IF
Description WB ; ICC ; IF
Dilution WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Dours-Zimmermann M.T. and Zimmermann D.R. (1994) J. Biol. Chem. 52: 32992-32998.

2. Evanko S.P., Angello J.C. and Wight T.N. (1999) Arterioscler. Thromb. Vasc. Biol. 4:1004-1013.

3. Lemire J.M., et al. (1999) Arterioscler. Thromb. Vasc. Biol. 7: 1630-1639.

4.Wight T.N. (2002) Curr. Opin. Cell Biol. 5: 617-623.

5. Touab M., Villena J., Barranco C., Arumi-Uria M. and Bassols A. (2002) Am. J. Pathol. 2: 549-557.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11904248-1 SMC-439D Unconjugated 100 ug $330
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BHA11904248-2 SMC-439D-A390 ATTO 390 100 ug $384
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BHA11904248-3 SMC-439D-A488 ATTO 488 100 ug $383
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BHA11904248-4 SMC-439D-A594 ATTO 594 100 ug $383
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BHA11904248-5 SMC-439D-ALP Alkaline Phosphatase 100 ug $376
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BHA11904248-6 SMC-439D-APC APC 100 ug $382
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BHA11904248-7 SMC-439D-BI Biotin 100 ug $378
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BHA11904248-8 SMC-439D-FITC FITC 100 ug $374
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BHA11904248-9 SMC-439D-HRP HRP 100 ug $370
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BHA11904248-10 SMC-439D-PCP PerCP 100 ug $382
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BHA11904248-11 SMC-439D-RPE RPE 100 ug $380
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BHA11904248-12 SMC-439S Unconjugated 12 ug $44
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