JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.
Loding Loading ....
Home / Primary Antibodies / Monoclonal Antibodies

TSP23 Antibody, Clone Tsp232A - SMC-194

BHA11901472
Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Request More Infos
Order Now

Credit card payments now incur a 3% fee.

Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
Request More Infos
Sample Request
Swissprot B9A003
Accession Number NP_001136126.1
Gene Id 80755
Target TSP23
Clone No Tsp232A
Research Area Cancer, Heat Shock, Cell Signaling, Epigenetics and Nuclear Signaling
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate–mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology. Specifically TSP23 (transcript similar p23) displays 44% and 17% amino acid identity with p23 and Sba1p respectively (10).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~19kDa. Detects Tsp23, no cross-reactivity to p23.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, IHC, WB
Description WB ; IHC ; AM
Dilution WB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Johnson J.L., Beito T. G., Krco C.J., Toft D.O. (1994) Mol Cell Biol 14: 1956-63.

2. Weikl T., Abelmann K., Buchner J. (1999) J Mol Biol 293: 685-91.

3. Weaver A.J., Sullivan W.P., Felts S.J., Owen B.A., Toft D.O. (2000) J Biol Chem 275: 23045-52.

4. Nair S.C., et al. (1996) Cell Stress Chaperones 1: 237-50.

5. Xu Z., et al. (1997) Eur J Biochem 246, 461-70.

6. Holt S.E., et al. (1999) Genes Dev 13: 817-26.

7. Hu J., Toft D., Anselmo D., Wang X. (2002) J Virol 76: 269-79.

8. Felts, S.J., Toft D.O. (2003) Cell Stress Chaperones.8: 108-13.

9. Gausdal G., Gjertsen B.T., Fladmark K.E., Demol H., Vandekerckhove J. & Doskeland S.O. (2004) Leukemia

10. Freeman B.C., Felts S.J., Toft D.O., Yamamato K.R. (2000) Genes Dev. 14(4): 433-434.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11901472-1 SMC-194D Unconjugated 100 ug $306
Add to Cart
BHA11901472-2 SMC-194D-A390 ATTO 390 100 ug $360
Add to Cart
BHA11901472-3 SMC-194D-A488 ATTO 488 100 ug $359
Add to Cart
BHA11901472-4 SMC-194D-A594 ATTO 594 100 ug $359
Add to Cart
BHA11901472-5 SMC-194D-ALP Alkaline Phosphatase 100 ug $352
Add to Cart
BHA11901472-6 SMC-194D-APC APC 100 ug $358
Add to Cart
BHA11901472-7 SMC-194D-BI Biotin 100 ug $354
Add to Cart
BHA11901472-8 SMC-194D-FITC FITC 100 ug $350
Add to Cart
BHA11901472-9 SMC-194D-HRP HRP 100 ug $345
Add to Cart
BHA11901472-10 SMC-194D-PCP PerCP 100 ug $358
Add to Cart
BHA11901472-11 SMC-194D-RPE RPE 100 ug $355
Add to Cart
BHA11901472-12 SMC-194S Unconjugated 12 ug $44
Add to Cart