Mouse Anti-Human Trap1 Monoclonal IgG2a Kappa

Mfr.No.	SMC-193, SMC-193D, SMC-193D-A390, SMC-193D-A488, SMC-193D-A594, SMC-193D-ALP, SMC-193D-APC, SMC-193D-BI, SMC-193D-FITC, SMC-193D-HRP, SMC-193D-PCP, SMC-193D-RPE, SMC-193S
Immunogen Species	Human
Alternative Names	Heat shock protein 75 Antibody, Heat shock protein 75 kDa Antibody, Heat shock protein 75 kDa mitochondrial Antibody, HSP 75 Antibody, HSP 90L Antibody, HSP75 Antibody, HSP90L Antibody, mitochondrial Antibody, TNF receptor associated protein 1 Antibody, TNFR associated protein 1 Antibody, TNFR-associated protein 1 Antibody, TRAP 1 Antibody, TRAP-1 Antibody, Trap1 Antibody, TRAP1_HUMAN Antibody, Tumor necrosis factor receptor associated protein Antibody, Tumor necrosis factor type 1 receptor associated protein Antibody, Tumor necrosis factor type 1 receptor-associated protein Antibody
Categories	Antibodies
Cellular Localization	Mitochondrion
Certificate Of Analysis	1 ug/ml of SMC-193 was sufficient for detection of Trap-1/HSP75 in 20 ug of Hela Cell lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Human Trap1 Monoclonal IgG2a Kappa
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Purified recombinant full length TRAP1 (no tags), Homo Sapiens (Human)
Immunogen Region	Human purified recombinant full length TRAP1 (no tags)
Isotype	IgG2a Kappa
Launch Date	2011/05/05
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human

Swissprot	Q12931
Accession Number	NP_057376.2
Gene Id	10131
Target	TRAP1
Clone No	Trap1-6
Research Area	Cancer, Heat Shock, Cell Signaling, Protein Trafficking

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	The 90 kDa heat shock protein (HSP90) family of proteins that play an important physiological role. HSP90 is involved in numerous cellular processes but is best known for its association with signal transduction machinery. A recently cloned homolog of HSP90 is the tumor necrosis factor receptor-associated protein (TRAP1). Like HSP90, TRAP1 is found to be associated with numerous proteins involved in diverse actions (1, 2). Immunofluorescence data has shown TRAP1 to be localized in the mitochondria of mammalian cells. This observation and the fact that TRAP1 is shown to have a mitochondrial targeting pre-sequence strongly implicates TRAP1 as a mitochondrial matrix protein (3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~75kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, ICC/IF
Description	WB ; ICC ; IF
Dilution	WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Felts S.J., et al. (2000) J Biol Chem. 275(5): 3305-3312. 2. Costantino E., et al. (2009) Cancer Lett. 279(1): 39-46. 3. Cechetto J.D., Gupta R.S. (2000) Exp Cell Res. 260(1): 30-39.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11901453-1	SMC-193D	Unconjugated	100 ug	$306	Add to Cart
BHA11901453-2	SMC-193D-A390	ATTO 390	100 ug	$360	Add to Cart
BHA11901453-3	SMC-193D-A488	ATTO 488	100 ug	$359	Add to Cart
BHA11901453-4	SMC-193D-A594	ATTO 594	100 ug	$359	Add to Cart
BHA11901453-5	SMC-193D-ALP	Alkaline Phosphatase	100 ug	$352	Add to Cart
BHA11901453-6	SMC-193D-APC	APC	100 ug	$358	Add to Cart
BHA11901453-7	SMC-193D-BI	Biotin	100 ug	$354	Add to Cart
BHA11901453-8	SMC-193D-FITC	FITC	100 ug	$350	Add to Cart
BHA11901453-9	SMC-193D-HRP	HRP	100 ug	$345	Add to Cart
BHA11901453-10	SMC-193D-PCP	PerCP	100 ug	$358	Add to Cart
BHA11901453-11	SMC-193D-RPE	RPE	100 ug	$355	Add to Cart
BHA11901453-12	SMC-193S	Unconjugated	12 ug	$44	Add to Cart

TRAP1 Antibody, Clone Trap1-6 - SMC-193

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