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Home / Primary Antibodies / Monoclonal Antibodies

TP53 Monoclonal Antibody

SKU : BHA10561290

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-MA989534
Alternative Names	P53; LFS1; TRP53; TP53
Categories	Primary Antibodies
Clonality	monoclonal
Description	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Host	Mouse
Immunogen	Purified recombinant Human p53 protein fragments expressed in E.coli.
Isotype	IgG2b
Raised In	Mouse
Reactivity	Human
Regulatory	RUO
Relevance	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Species	Homo Sapiens (Human)
Specificity	This antibody detects endogenous levels of p53 and does not cross-react with related proteins.

Gene Id	7157
Clone No	6C4-C12-H10
Weight	43.7kDa

Buffer	Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Description	This antibody detects endogenous levels of p53 and does not cross-react with related proteins.
Form	Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Affinity purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:5000

Tested Application

ELISA,WB;Recommended dilution:WB:1:500-1:5000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10561290	CSB-MA989534	100ul	$384		Add to Cart

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