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Home / Primary Antibodies / Monoclonal Antibodies

TNF alpha antibody

SKU : BHA10808807

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Mfr.No.	FNab08815
Alternative Names	Cachectin ; DIF ; TNF ; TNFa ; TNFalpha ; TNFA ; TNF-a ; TNFSF2 ; Tumornecrosisfactor
Background	TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor(TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme(TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Categories	Primary Antibodies
Clonality	monoclonal
Description	TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Host	Mouse
Immunogen	tumor necrosis factor(TNF superfamily, member 2)
Isotype	IgG2b
Molecular Weight	22 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	Cachectin, DIF, TNF, TNF a, TNF alpha, TNFA, TNF-a, TNFSF2, Tumor necrosis factor

Uniprot	P01375
Clone No	2A9
Research Area	Signal Transduction, Cardiovascular, Cancer, Immunology, Neuroscience
Weight	22kDa

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:500-1:5000

Tested Application

WB: 1:500-1:5000; IHC: 1:200-1:1000

Manual	FNab08815.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808807	FNab08815	100ug	$300		Add to Cart

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