Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES(By similarity).
Categories
Primary Antibodies
Clonality
monoclonal
Description
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Host
Mouse
Immunogen
transducin-like enhancer of split 3(E(sp1) homolog, Drosophila)
Isotype
IgG1
Molecular Weight
90 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
KIAA1547
Uniprot
Q04726
Gene Id
7090
Clone No
8D6
Research Area
Developmental biology, Stem Cells, Signal Transduction, Metabolism
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)