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Home / Primary Antibodies / Monoclonal Antibodies

TCP1 alpha Antibody, Clone 23c - SMC-478

BHA11904951
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Tel
+1 866.986.9598
Email
[email protected]
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Swissprot P11983
Accession Number NP_038714.2
Gene Id 21454
Target TCP1 alpha
Clone No 23c
Research Area Cancer, Heat Shock, Cell Signaling, Protein Trafficking
Buffer PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background T-complex polypeptide-1 (TCP1) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells, and is up-regulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin. The family of proteins termed chaperonins act to recognize and stabilize polypeptide intermediates during folding, assembly and disassembly, and share many characteristics with Heat Shock Protein 70 (HSP 70) including high abundance, induction by environmental stress, and ATPase activity. The chaperonin family includes the mitochondrial HSP60, Escherichia coli GroEL, the plastid Rubisco-subunit binding protein, and the archaebacterial protein TF55. The TCP1 sequence shows nearly 40% identity to TF55, but only minimal similarity to HSP60 and GroEL.
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~60kDa. Also detects ~92kDa. The addition of an alanine (LDDA COOH) prevents binding in ELISA assays to immobilized synthetic peptide sequences. This antibody recognizes other proteins, most notably the p102B' COP subunit of Golgi coatomer. It does not react with human HSP60 protein.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IP, WB, ICC/IF
Description WB ; ICC ; IF ; IP
Dilution WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11904951-1 SMC-478D Unconjugated 100 ug $306
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BHA11904951-2 SMC-478D-A390 ATTO 390 100 ug $360
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BHA11904951-3 SMC-478D-A488 ATTO 488 100 ug $359
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BHA11904951-4 SMC-478D-A594 ATTO 594 100 ug $359
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BHA11904951-5 SMC-478D-ALP Alkaline Phosphatase 100 ug $352
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BHA11904951-6 SMC-478D-APC APC 100 ug $358
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BHA11904951-7 SMC-478D-BI Biotin 100 ug $354
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BHA11904951-8 SMC-478D-FITC FITC 100 ug $350
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BHA11904951-9 SMC-478D-HRP HRP 100 ug $345
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BHA11904951-10 SMC-478D-PCP PerCP 100 ug $358
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BHA11904951-11 SMC-478D-RPE RPE 100 ug $355
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BHA11904951-12 SMC-478S Unconjugated 12 ug $44
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