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Home / Primary Antibodies / Monoclonal Antibodies

SHANK3 Antibody, Clone S69 - SMC-336

BHA11903089
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+1 866.986.9598
Email
[email protected]
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Swissprot Q9JLU4
Accession Number NP_067708.1
Gene Id 59312
Target SHANK3
Clone No S69
Research Area Cell Markers, Neuron Markers, Postsynaptic Markers, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (2). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (3).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~190kDa. No cross-reactivity against Shank1 or Shank2.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP ; AM
Dilution WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856.

2. Schuetz G., et al. (2004) JCB. 167(5): 645-952.

3. Durand C.M., et al. (2007) Nature Genetics. 39: 25-27.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11903089-1 SMC-336D Unconjugated 100 ug $330
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BHA11903089-2 SMC-336D-A390 ATTO 390 100 ug $384
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BHA11903089-3 SMC-336D-A488 ATTO 488 100 ug $383
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BHA11903089-4 SMC-336D-A594 ATTO 594 100 ug $383
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BHA11903089-5 SMC-336D-ALP Alkaline Phosphatase 100 ug $376
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BHA11903089-6 SMC-336D-APC APC 100 ug $382
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BHA11903089-7 SMC-336D-BI Biotin 100 ug $378
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BHA11903089-8 SMC-336D-FITC FITC 100 ug $374
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BHA11903089-9 SMC-336D-HRP HRP 100 ug $370
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BHA11903089-10 SMC-336D-PCP PerCP 100 ug $382
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BHA11903089-11 SMC-336D-RPE RPE 100 ug $380
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BHA11903089-12 SMC-336S Unconjugated 12 ug $44
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