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Home / Primary Antibodies / Monoclonal Antibodies

RANKL antibody

SKU : BHA10809830

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Mfr.No.	FNab09838
Background	TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
Clonality	monoclonal
Host	Mouse
Immunogen	tumor necrosis factor (ligand) superfamily, member 11
Immunogen Region	tumor necrosis factor (ligand) superfamily, member 11
Isotype	IgG1
Molecular Weight	35 kDa
Reactivity	Human
Recommended Dilution	WB: 1:1000-1:5000
Synonyms	CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoprotegerin ligand, RANKL, sOdf, TNFSF11, TRANCE

Uniprot	O14788
Gene Id	8600
Clone No	4F11
Research Area	Developmental biology, Immunology, Signal Transduction

Form	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:1000-1:5000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09838.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809830	FNab09838	100ug	$280		Add to Cart

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