homolog of B; RAD23B; RD23B_HUMAN; UV excision repair protein RAD23 homolog B; XP C repair complementing complex 58 kDa; XP C repair complementing complex 58 kDa protein; XP C repair complementing protein; XP-C repair-complementing complex 58 kDa protein;
Categories
Primary Antibodies
Clonality
monoclonal
Description
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.
Host
Mouse
Immunogen
Purified recombinant Human hHR23b protein fragments expressed in E.coli.
Isotype
IgG2b
Raised In
Mouse
Reactivity
Hamster, Monkey, Human, Mouse, Rat
Regulatory
RUO
Relevance
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.
Species
Homo Sapiens (Human)
Specificity
This antibody detects endogenous levels of hHR23b and does not cross-react with related proteins.
Buffer
Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Description
This antibody detects endogenous levels of hHR23b and does not cross-react with related proteins.
Form
Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Affinity purified
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.