Binds cholesterol in cholesterol-containing plasma membrane microdomains.Proposed to play a role in apical plasma membrane organization of epithelial cells.During early retinal development acts as a key regulator of disk morphogenesis.Involved in regulation of MAPK and Akt signaling pathways.In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
Host
Mouse
Immunogen
Purified recombinant Human PROM1 protein fragments expressed in E.coli.
Isotype
IgG2a
Raised In
Mouse
Reactivity
Human
Regulatory
RUO
Relevance
Binds cholesterol in cholesterol-containing plasma membrane microdomains.Proposed to play a role in apical plasma membrane organization of epithelial cells.During early retinal development acts as a key regulator of disk morphogenesis.Involved in regulation of MAPK and Akt signaling pathways.In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
Species
Homo Sapiens (Human)
Specificity
This antibody detects endogenous levels of PROM1 and does not cross-react with related proteins.
Gene Id
8842
Weight
97202
Buffer
Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Description
This antibody detects endogenous levels of PROM1 and does not cross-react with related proteins.
Form
Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Format
liquid
Purification
Affinity purified
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.