PPM1H Antibody, Clone 10D2

Mfr.No.	SMC-616, SMC-616, SMC-616D, SMC-616D-A390, SMC-616D-A488, SMC-616D-A594, SMC-616D-ALP, SMC-616D-APC, SMC-616D-BI, SMC-616D-FITC, SMC-616D-HRP, SMC-616D-PCP, SMC-616D-RPE, SMC-616S
Immunogen Species	Human
Alternative Names	Protein phosphatase Mg2+/Mn2+ dependent 1H Antibody \| NERPP2C \| Protein phosphatase 1H Antibody
Antigen	PPM1H
Categories	Antibodies
Cellular Localization	Intracellular
Certificate Of Analysis	A 1:1000 dilution of SMC-616 was sufficient for detection of PPM1H in 10 ug of Hu, Ms, Rt Kidney Cells (HEK293), Alveolar Basal Epithelial cells (A549) by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Conjugate	Unconjugated, ATTO 390, ATTO 488, ATTO 594, Alkaline Phosphatase, APC, Biotin, FITC, HRP, PerCP, RPE
Description	Human Anti-Human PPM1H Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen Region	Recombinant Human PPM1H Protein
Isotype	IgG1
Launch Date	2023/04/05
Net Weight (g)	0.1
Reactivity	Human, Mouse, Rat
Species Reactivity Medium	Mouse, Rat, Human
Tissue Specificity	Parathyroid gland

Swissprot	Q9ULR3
Accession Number	NP_065751.1
Gene Id	57460
Clone No	10D2
Research Area	Neurodegeneration, Parkinson's Disease, Cancer, Tumor Biomarkers, Oncoproteins, Signal Transducers, Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, Neuroscience

Concentration	1mg/ml
Purification	Protein G Purified
Scientific Background	PPM1H is an independent prognostic biomarker of non-small cell lung cancer (1). PPM1H acts as a key modulator of LRRK2 signaling by controlling dephosphorylation of Rab proteins (2). PPM1H is also suggested to be a gatekeeper to prevent excessive bone morphogenetic protein (BMP) signalling through dephosphorylation (3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~55kDa
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, ICC/IF
Dilution	WB (1:1000), ICC/IF (1:500); optimal dilutions for assays should be determined by the user.

Product Manual	SDS

Reference	1. Zhang W.Q., et al. (2021) Neoplasma. 68(5): 917-923. 2. Berndsen K., et al. (2019) 8:e50416. 3.Shen T., et al. (2014) Cell Res. 24(6): 727-741.

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Combination SKU	Supplier No.	Size	Conjugate	Your price
BHA11933475-2	SMC-616D	100 ug	Unconjugated	$387	Add to Cart
BHA11933475-3	SMC-616D-A390	100 ug	ATTO 390	$436	Add to Cart
BHA11933475-4	SMC-616D-A488	100 ug	ATTO 488	$435	Add to Cart
BHA11933475-5	SMC-616D-A594	100 ug	ATTO 594	$435	Add to Cart
BHA11933475-6	SMC-616D-ALP	100 ug	Alkaline Phosphatase	$429	Add to Cart
BHA11933475-7	SMC-616D-APC	100 ug	APC	$434	Add to Cart
BHA11933475-8	SMC-616D-BI	100 ug	Biotin	$431	Add to Cart
BHA11933475-9	SMC-616D-FITC	100 ug	FITC	$427	Add to Cart
BHA11933475-10	SMC-616D-HRP	100 ug	HRP	$423	Add to Cart
BHA11933475-11	SMC-616D-PCP	100 ug	PerCP	$434	Add to Cart
BHA11933475-12	SMC-616D-RPE	100 ug	RPE	$432	Add to Cart
BHA11933475-13	SMC-616S	12 ug	Unconjugated	$44	Add to Cart

PPM1H Antibody, Clone 10D2 - SMC-616