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Home / Primary Antibodies / Monoclonal Antibodies

Phospho-PAK4/PAK5/PAK6 (S474/S560/S602) Antibody

SKU : BHA10564540

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RA017408A474phHU
Alternative Names	Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4, PAK4, KIAA1142
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Immunogen	A synthesized peptide derived from Human Phospho-PAK4/PAK5/PAK6 (S474/S560/S602)
Isotype	IgG
Reactivity	Human
Relevance	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

Uniprot	O96013 Q9P286 Q9NQU5
Gene Name	PAK4/PAK5/PAK6
Research Area	Cell Biology

Form	Liquid
Purification	Affinity-chromatography
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Description	WB ; ELISA ; IF
Tested Application	ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:20-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10564540	CSB-RA017408A474phHU	100ul	$350		Add to Cart
BHA10564540	CSB-RA017408A474phHU	50ul	$210		Add to Cart

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