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Home / Primary Antibodies / Monoclonal Antibodies

Phospho-PAK1/PAK2/PAK3 (S144+S141+S139) Antibody

SKU : BHA10564422

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RA017407A144phHU
Alternative Names	Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Immunogen	A synthesized peptide derived from Human Phospho-PAK1/PAK2/PAK3 (S144+S141+S139)
Isotype	IgG
Reactivity	Human
Relevance	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

Uniprot	O75914 Q13153 Q13177
Gene Name	PAK3/PAK1/PAK2
Research Area	Neuroscience

Form	Liquid
Purification	Affinity-chromatography
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Description	WB ; ELISA ; IHC
Tested Application	ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10564422	CSB-RA017407A144phHU	100ul	$350		Add to Cart
BHA10564422	CSB-RA017407A144phHU	50ul	$210		Add to Cart

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