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Home / Primary Antibodies / Monoclonal Antibodies

Phospho-LAT (Y191) Antibody

SKU : BHA10564429

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RA012767A191phHU
Alternative Names	Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, pp36, p36-38, LAT
Antigen	LAT
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Conjugate	Non-conjugated
Immunogen	A synthesized peptide derived from Human Phospho-LAT (Y191)
Involvement In Disease	Immunodeficiency 52 (IMD52)
Isotype	IgG
Reactivity	Human
Relevance	Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Subcellular Location	Cell membrane, Single-pass type III membrane protein

Uniprot	O43561
Gene Name	LAT
Database Links	HGNC:18874 OMIM:602354 KEGG:hsa:27040 UniGene:Hs.632179
Function	Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Pathway	NF-kappa B signaling pathway Ras signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Natural killer cell mediated cytotoxicity T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Rap1 signaling pathway
Research Area	Immunology
Tissue Specificity	Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).

Form	Liquid
Purification	Affinity-chromatography
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Description	IHC ; IF ; IP ; WB ; ELISA
Tested Application	ELISA, WB, IHC, IF, IP; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200, IP:1:200-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunoprecipitation (IP) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10564429	CSB-RA012767A191phHU	100ul	$350		Add to Cart
BHA10564429	CSB-RA012767A191phHU	50ul	$210		Add to Cart

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