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Home / Primary Antibodies / Monoclonal Antibodies

Phospho-JAK2 (Y1007 + Y1008) Antibody

SKU : BHA10564394

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RA011931A100phHU
Alternative Names	Tyrosine-protein kinase JAK2, Janus kinase 2, JAK-2, JAK2
Antigen	JAK2
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Conjugate	Non-conjugated
Immunogen	A synthesized peptide derived from Human Phospho-JAK2 (Y1007 + Y1008)
Involvement In Disease	Budd-Chiari syndrome (BDCHS); Polycythemia vera (PV); Thrombocythemia 3 (THCYT3); Myelofibrosis (MYELOF); Leukemia, acute myelogenous (AML)
Isotype	IgG
Reactivity	Human
Relevance	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980).
Subcellular Location	Endomembrane system, Peripheral membrane protein, Cytoplasm, Nucleus

Uniprot	O60674
Gene Name	JAK2
Database Links	HGNC:6192 OMIM:147796 KEGG:hsa:3717 STRING:9606.ENSP00000371067 UniGene:Hs.656213
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins
Pathway	Chemokine signaling pathway Jak-STAT signaling pathway PI3K-Akt signaling pathway Necroptosis Signaling pathways regulating pluripotency of stem cells Th1 and Th2 cell differentiation Th17 cell differentiation Adipocytokine signaling pathway AGE-RAGE signaling pathway in diabetic complications
Protein Families	Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Research Area	Cell Biology
Tissue Specificity	Ubiquitously expressed throughout most tissues.

Form	Liquid
Purification	Affinity-chromatography
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Description	WB ; ELISA ; IHC ; IP
Tested Application	ELISA, WB, IHC, IP; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IP:1:200-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunoprecipitation (IP) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10564394	CSB-RA011931A100phHU	100ul	$350		Add to Cart
BHA10564394	CSB-RA011931A100phHU	50ul	$210		Add to Cart

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