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Home / Primary Antibodies / Monoclonal Antibodies

Phospho-GSK3A/GSK3B (Y216 + Y279) Antibody

SKU : BHA10564595

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RA009962A216phHU
Alternative Names	Glycogen synthase kinase-3 alpha, GSK-3 alpha, Serine/threonine-protein kinase GSK3A, GSK3A
Antigen	GSK3A
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Conjugate	Non-conjugated
Immunogen	A synthesized peptide derived from Human Phospho-GSK3A/GSK3B (Y216 + Y279)
Isotype	IgG
Reactivity	Human
Relevance	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

Uniprot	P49840
Gene Name	GSK3A
Database Links	HGNC:4616 OMIM:606784 KEGG:hsa:2931 STRING:9606.ENSP00000222330 UniGene:Hs.466828
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Pathway	Chemokine signaling pathway
Protein Families	Protein kinase superfamily, CMGC Ser/Thr protein kinase family, GSK-3 subfamily
Research Area	Neuroscience

Form	Liquid
Purification	Affinity-chromatography
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Description	IHC ; ELISA
Tested Application	ELISA, IHC; Recommended dilution: IHC:1:50-1:200

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10564595	CSB-RA009962A216phHU	100ul	$350		Add to Cart
BHA10564595	CSB-RA009962A216phHU	50ul	$210		Add to Cart

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