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Home / Primary Antibodies / Monoclonal Antibodies

p23 Antibody, Clone JJ6 - SMC-156

BHA11900820
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+1 866.986.9598
Email
[email protected]
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Swissprot Q15185
Accession Number NP_006592.3
Gene Id 10728
Target p23
Clone No JJ6
Research Area Cancer, Heat Shock, Cell Signaling, Epigenetics and Nuclear Signaling, Chaperone Proteins, Metabolism, Lipid and Lipoprotein Metabolism, Protein Trafficking
Buffer PBS, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:2000) IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the HSP90-progesterone receptor complex along with HSP70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate–mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~23kDa.
Storage -20ºC
Storage Buffer PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, ELISA, IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP ; ELISA ; AM
Dilution WB (1:2000) IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Johnson J.L., Beito T. G., Krco C.J. & Toft D.O. (1994) Mol Cell Biol 14: 1956-63.

2. Weikl T., Abelmann K. & Buchner J. (1999) J Mol Biol 293: 685-91.

3. Weaver A.J., Sullivan W.P., Felts S.J., Owen B.A. & Toft, D.O. (2000) J Biol Chem 275: 23045-52.

4. Nair S.C., et al. (1996) Cell Stress Chaperones 1: 237-50.

5. Xu Z., et al. (1997) Eur J Biochem 246, 461-70.

6. Holt S.E., et al. (1999) Genes Dev 13: 817-26.

7. Hu J., Toft D., Anselmo D. & Wang X. (2002) J Virol 76: 269-79.

8. Felts, S.J. & Toft D.O. (2003) Cell Stress Chaperones 8: 108-13.

9. Gausdal G., Gjertsen B.T., Fladmark K.E., Demol H., Vandekerckhove J. & Doskeland S.O. (2004) Leukemia.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11900820-1 SMC-156D Unconjugated 100 ug $272
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BHA11900820-2 SMC-156C Unconjugated 25 ug $121
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BHA11900820-3 SMC-156D-A390 ATTO 390 100 ug $326
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BHA11900820-4 SMC-156D-A488 ATTO 488 100 ug $325
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BHA11900820-5 SMC-156D-A594 ATTO 594 100 ug $325
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BHA11900820-6 SMC-156D-ALP Alkaline Phosphatase 100 ug $318
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BHA11900820-7 SMC-156D-APC APC 100 ug $323
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BHA11900820-8 SMC-156D-BI Biotin 100 ug $320
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BHA11900820-9 SMC-156D-FITC FITC 100 ug $316
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BHA11900820-10 SMC-156D-HRP HRP 100 ug $311
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BHA11900820-11 SMC-156D-PCP PerCP 100 ug $323
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BHA11900820-12 SMC-156D-RPE RPE 100 ug $321
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BHA11900820-13 SMC-156S Unconjugated 12 ug $44
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