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Home / Primary Antibodies / Monoclonal Antibodies

NrCAM Antibody, Clone S364-51 - SMC-462

BHA11904647
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+1 866.986.9598
Email
[email protected]
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Swissprot Q810U4
Accession Number NP_001139503.1
Gene Id 319504
Target NrCAM
Clone No S364-51
Research Area Cell Markers, Neuron Markers, Membrane Markers, Neuroscience
Buffer PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background Neuronal cell adhesion molecule (NrCAM) is a cell surface protein of the immunoglobulin (Ig) superfamily. NrCAM (also known as Bravo) contains six Ig domains, five fibronectin repeats, a transmembrane region and an intracellular domain. NrCAM is expressed in brain, spinal cord, peripheral nervous system and pancreas. In the spinal cord, NrCAM acts as a ligand for axonin-1 to guide commissural axons across the floor plate. NrCAM also acts as a ligand for F3 to control actin-dependent growth cone motility. NrCAM interacts with neurofascin and may facilitate the clustering of the cystoskeletal protein ankyrin G and the voltage-dependent sodium channel proteins at the node of Ranvier. NrCAM expression may play a role in the severity of certain types of tumors. NrCAM is overexpressed in high-grade astrocytomas, gliomas and glioblastoma tumor tissues.
In the pancreas, NrCAM expression is upregulated in intraductal hyperplasia. Antisense NrCAM reduces the tumorigenic properties of human glioblastoma cells in vitro and slowed tumor growth in vivo. The gene encoding human NrCAM maps to chromosome 7q31.1-q31.2.
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~160kDa.
Storage -20ºC
Storage Buffer PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications WB, ICC/IF
Description WB ; ICC ; IF
Dilution WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11904647-1 SMC-462D Unconjugated 100 ug $330
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BHA11904647-2 SMC-462D-A390 ATTO 390 100 ug $384
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BHA11904647-3 SMC-462D-A488 ATTO 488 100 ug $383
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BHA11904647-4 SMC-462D-A594 ATTO 594 100 ug $383
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BHA11904647-5 SMC-462D-ALP Alkaline Phosphatase 100 ug $376
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BHA11904647-6 SMC-462D-APC APC 100 ug $382
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BHA11904647-7 SMC-462D-BI Biotin 100 ug $378
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BHA11904647-8 SMC-462D-FITC FITC 100 ug $374
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BHA11904647-9 SMC-462D-HRP HRP 100 ug $370
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BHA11904647-10 SMC-462D-PCP PerCP 100 ug $382
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BHA11904647-11 SMC-462D-RPE RPE 100 ug $380
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BHA11904647-12 SMC-462S Unconjugated 12 ug $44
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