Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus(PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues(PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity(PubMed:15044100). Binds to G-quadruplex structures in mRNA(PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U)(PubMed:16571602).
Categories
Primary Antibodies
Clonality
monoclonal
Description
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).
Host
Mouse
Immunogen
microspherule protein 1
Isotype
IgG2a
Molecular Weight
55 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
INO80Q, MSP58
Uniprot
Q96EZ8
Gene Id
10445
Clone No
5G3
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)