Mouse Anti-Mouse LGI1 Monoclonal IgG2a

Mfr.No.	SMC-461, SMC-461D, SMC-461D-A390, SMC-461D-A488, SMC-461D-A594, SMC-461D-ALP, SMC-461D-APC, SMC-461D-BI, SMC-461D-FITC, SMC-461D-HRP, SMC-461D-PCP, SMC-461D-RPE, SMC-461S
Immunogen Species	Mouse
Alternative Names	ADLTE Antibody, ADPAEF Antibody, ADPEAF Antibody, Epitempin 1 Antibody, EPT Antibody, ETL1 Antibody, IB1099 Antibody, leucine rich glioma inactivated 1 Antibody, OTTHUMP00000020121 Antibody, OTTHUMP00000020122 Antibody
Categories	Antibodies
Cellular Localization	Endoplasmic Reticulum, Cell Junction, Golgi Apparatus
Certificate Of Analysis	1 ug/ml of SMC-461 was sufficient for detection of LGI1 in 20 ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Mouse LGI1 Monoclonal IgG2a
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1. Rat: 100% identity (77/77 amino acids identical). Human: 98% identity (76/77 amino acids identical). ~50% identity with LGI2, LGI3 and LGI4., Mus Musculus (Mouse)
Immunogen Region	Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1. Rat: 100% identity (77/77 amino acids identical). Human: 98% identity (76/77 amino acids identical). ~50% identity with LGI2, LGI3 and LGI4.
Isotype	IgG2a
Launch Date	2013/09/26
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Mus Musculus (Mouse)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q9JIA1.1
Accession Number	NP_064674.1
Gene Id	56839
Target	LGI1
Clone No	S283-7
Research Area	Neurodegeneration, Cell Signaling, Epigenetics and Nuclear Signaling, Cancer, Neuroscience

Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist; this LGI1 antibody will recognize only the longer form.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~60kDa.
Storage	-20ºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Chernova O.B., Somerville R.P. and Cowell J.K. (1998) Oncogene. 17:2873-81. 2. Fialka F., et al. (2008) Oral Oncol. 3. Gu W., et al. (2005) Mol. Biol. Evol. 22:2209-16. 4. Fukata Y., et al. (2006) Science. 313:1792-5.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11904628-1	SMC-461D	Unconjugated	100 ug	$330	Add to Cart
BHA11904628-2	SMC-461D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11904628-3	SMC-461D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11904628-4	SMC-461D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11904628-5	SMC-461D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11904628-6	SMC-461D-APC	APC	100 ug	$382	Add to Cart
BHA11904628-7	SMC-461D-BI	Biotin	100 ug	$378	Add to Cart
BHA11904628-8	SMC-461D-FITC	FITC	100 ug	$374	Add to Cart
BHA11904628-9	SMC-461D-HRP	HRP	100 ug	$370	Add to Cart
BHA11904628-10	SMC-461D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11904628-11	SMC-461D-RPE	RPE	100 ug	$380	Add to Cart
BHA11904628-12	SMC-461S	Unconjugated	12 ug	$44	Add to Cart

LGI1 Antibody, Clone S283-7 - SMC-461

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