Mouse Anti-Rat Kir6.1 Monoclonal IgG2A

Mfr.No.	SMC-491, SMC-491D, SMC-491D-A390, SMC-491D-A488, SMC-491D-A594, SMC-491D-ALP, SMC-491D-APC, SMC-491D-BI, SMC-491D-FITC, SMC-491D-HRP, SMC-491D-PCP, SMC-491D-RPE, SMC-491S
Immunogen Species	Rat
Alternative Names	ATP-sensitive inward rectifier potassium channel 8 Antibody, Potassium channel inwardly rectifying subfamily J member 8 Antibody, uKATP-1 Antibody, Kcnj8 Antibody
Categories	Antibodies
Cellular Localization	Membrane
Certificate Of Analysis	A 1:100 dilution of SMC-491 was sufficient for detection of Kir6.1 in 20 ug of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Rat Kir6.1 Monoclonal IgG2A
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1, Rattus Norvegicus (Rat)
Immunogen Region	Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
Isotype	IgG2A
Launch Date	2015/03/10
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Rattus Norvegicus (Rat)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q63664
Accession Number	NP_058795.3
Gene Id	25472
Target	Kir6.1
Clone No	S366-60
Research Area	Ion channels, Potassium Channels, Inward-Rectifying Potassium Channels, Cancer, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~45kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Zobel C., et al. (2003) J Physiol. 550: 365-372. 2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567. 3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496. 4. Aguilar-Bryan L., et al. (1998) Physiol Rev. 78(1): 227-245.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11905198-1	SMC-491D	Unconjugated	100 ug	$330	Add to Cart
BHA11905198-2	SMC-491D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11905198-3	SMC-491D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11905198-4	SMC-491D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11905198-5	SMC-491D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11905198-6	SMC-491D-APC	APC	100 ug	$382	Add to Cart
BHA11905198-7	SMC-491D-BI	Biotin	100 ug	$378	Add to Cart
BHA11905198-8	SMC-491D-FITC	FITC	100 ug	$374	Add to Cart
BHA11905198-9	SMC-491D-HRP	HRP	100 ug	$370	Add to Cart
BHA11905198-10	SMC-491D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11905198-11	SMC-491D-RPE	RPE	100 ug	$380	Add to Cart
BHA11905198-12	SMC-491S	Unconjugated	12 ug	$44	Add to Cart

Kir6.1 Antibody, Clone S366-60 - SMC-491