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Home / Primary Antibodies / Monoclonal Antibodies

Granzyme B

SKU : BHA15100427

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BioGenex Laboratories

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Mfr.No.	AM996-5M
Clonality	Monoclonal
Description	Granzyme B is a single chain and single domain serine protease. Its structure is folded into two six-stranded Beta-barrels, which are connected by three trans-domain segments. Granzyme B is one of the most common serine proteases present in the granules of Natural killer cells and cytotoxic T lymphocytes. Granzyme B is stored in secretory granules and secreted along with many other proteins such as perforin to induce apoptosis of harmful target cells such as allogeneic, virally infected and tumor cells. After being transported to the target cells, Granzyme B causes multiple cascades of activation and inactivation that ultimately leads to the apoptotic demise of the target cell. There is also some evidence that Granzyme B plays a role in moderating the immune response asides its apoptotic effects. Elevated levels of Granzyme B have been noticed in certain autoimmune diseases, further implicating its role in moderating the immune response. Granzyme B has potential to be effective in anti-cancer medicine, as Granzyme B and tumor fusion targeted therapeutics have shown promise in various models.
Host	Mouse
Isotype	IgG2b Kappa
Reactivity	Human
Species	Mouse

Clone No	GZMB/3014
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC

Product Manual	Datasheet SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
AM996-5M	AM996-5M	6ml RTU	$285		Add to Cart
AM996-10M	AM996-10M	100 tests - i6000	$531		Add to Cart
AX996-50D	AX996-50D	50 tests - Xmatrx	$297		Add to Cart
AX996-YCD	AX996-YCD	160 tests - Xmatrx	$727		Add to Cart
MU996-UC	MU996-UC	1ml Conc	$407		Add to Cart
MU996-5UC	MU996-5UC	0.5ml Conc	$583		Add to Cart

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