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Home / Primary Antibodies / Monoclonal Antibodies

GABA B Receptor 1 Antibody, Clone S93A-49 - SMC-403

BHA11903564
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+1 866.986.9598
Email
[email protected]
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Swissprot Q9Z0U4
Accession Number NP_112290.2
Gene Id 81657
Target GABA B Receptor 1
Clone No S93A-49
Research Area Neurotransmitter Receptors, GABA Receptors, GABAB Receptors, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~115kDa. No cross-reactivity against GABA(B)R2.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications WB, ICC/IF
Description WB ; ICC ; IF
Dilution WB (1:1000); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Jones K.A,. et al. (2000) Neuropsychopharmacology 23: S41-9.

2. Duthey B., et al. (2002) J Biol Chem. 277: 3236-41.

3. Kaupmann K., et al. (1997) Nature 386: 239-46.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11903564-1 SMC-403D Unconjugated 100 ug $330
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BHA11903564-2 SMC-403D-A390 ATTO 390 100 ug $384
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BHA11903564-3 SMC-403D-A488 ATTO 488 100 ug $383
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BHA11903564-4 SMC-403D-A594 ATTO 594 100 ug $383
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BHA11903564-5 SMC-403D-ALP Alkaline Phosphatase 100 ug $376
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BHA11903564-6 SMC-403D-APC APC 100 ug $382
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BHA11903564-7 SMC-403D-BI Biotin 100 ug $378
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BHA11903564-8 SMC-403D-FITC FITC 100 ug $374
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BHA11903564-9 SMC-403D-HRP HRP 100 ug $370
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BHA11903564-10 SMC-403D-PCP PerCP 100 ug $382
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BHA11903564-11 SMC-403D-RPE RPE 100 ug $380
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BHA11903564-12 SMC-403S Unconjugated 12 ug $44
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