lang=EN-US" style="font-size: 9pt; font-family: Arial, sans-serif; ">FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells."
Host
Mouse
Immunogen
Synthetic peptide conjugated to KLH derived from Human Heme Oxygenase 1.
Raised In
Mouse
Reactivity
Human
Regulatory
RUO
Relevance
FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.
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Species
Homo Sapiens (Human)
Specificity
FOXP3 antibody detects endogenous levels of total FOXP3
Buffer
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20掳C. Stable for 12 months from date of receipt.
Description
FOXP3 antibody detects endogenous levels of total FOXP3
Form
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20掳C. Stable for 12 months from date of receipt.
Format
liquid
Purification
Affinity-chromatography
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.