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Home / Primary Antibodies / Monoclonal Antibodies

CSK Monoclonal Antibody

SKU : BHA10561172

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-MA199199
Alternative Names	C SRC; C SRC kinase; C src Tyrosine Kinase; C-SRC kinase; c-src tyrosine kinase; Csk A; CSK; CSK_HUMAN; CYTOPLASMIC TYROSINE KINASE; EC2.7.10.2; MGC112926; MGC117393; MGC154049; P60 Src; Protein tyrosine kinase CYL; Protein-tyrosine kinase CYL;
Categories	Primary Antibodies
Clonality	monoclonal
Description	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Host	Mouse
Immunogen	Purified recombinant Human CSK protein fragments expressed in E.coli.
Isotype	IgG2b
Raised In	Mouse
Reactivity	Human, Rat
Regulatory	RUO
Relevance	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Species	Homo Sapiens (Human)
Specificity	This antibody detects endogenous levels of CSK and does not cross-react with related proteins.

Clone No	2B4-C6-A10

Buffer	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.2% sodium azide,0.1mg/mlBSA and 50% glycerol.
Description	This antibody detects endogenous levels of CSK and does not cross-react with related proteins.
Form	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.2% sodium azide,0.1mg/mlBSA and 50% glycerol.
Format	liquid
Purification	Affinity purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, ICC

Description

ELISA ; WB ; ICC, WB ; ELISA ; ICC

Dilution

WB	1:500-1:5000
ICC	1:50-1:200

Tested Application

ELISA,WB,ICC;Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10561172	CSB-MA199199	100ul	$384		Add to Cart

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