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Home / Primary Antibodies / Monoclonal Antibodies

Claudin-4

SKU : BHA15100447

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Mfr.No.	AMB08-5M
Clonality	Monoclonal
Description	Claudin-4 (Clostridium perfringens enterotoxin receptor) belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. It is a 209 amino acid molecule with four transmembrane segments. These are essential components of tight junction charge-specific channels that regulate paracellular ion flux. It plays a role in internal organ epithelial tissue development and function during pre- and postnatal life. Phosphorylation of Claudin-4 regulates paracellular epithelial permeability. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl- permeability. It is also up regulated in several carcinomas. Expression of Claudin-4 has been associated with either poor prognosis or a more favorable diagnosis, depending on the type of cancer. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. Claudin-4 has been shown to distinguish adenocarcinomas from malignant mesothelioma with 99% specificity in malignant effusions. Basal-like tumors also demonstrated overexpression of Claudin-4.
Host	Mouse
Isotype	IgG1
Reactivity	Human
Species	Mouse

Clone No	A-12
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:20-50

Product Manual	Datasheet SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
AMB08-5M	AMB08-5M	6 mL	$370		Add to Cart
AMB08-10M	AMB08-10M	100 tests - i6000	$693		Add to Cart
AXB08-50D	AXB08-50D	50 tests - Xmatrx	$390		Add to Cart
AXB08-YCD	AXB08-YCD	160 tests - Xmatrx	$948		Add to Cart
MUB08-UC	MUB08-UC	1ml Conc	$761		Add to Cart
MUB08-5UC	MUB08-5UC	0.5ml Conc	$531		Add to Cart

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