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Home / Primary Antibodies / Monoclonal Antibodies

Biotinylated Anti-CS1 antibody(DM10), Rabbit mAb

SKU : BHA18100126

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DIMA Biotechnology

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Mfr.No.	DME100010B
Antigen	CS1
Background	Self-ligand receptor of the signaling lymphocytic actIVation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the actIVation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptIVe immune response. ActIVIties are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell actIVation through a SH2D1A-independent eXtracellular signal-regulated ERK-mediated pathway (PubMed:11698418). PositIVely regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to actIVation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-actIVated monocytes negatIVely regulates production of proinflammatory cytokines (PubMed:23695528).
Clonality	Monoclonal
Host	Rabbit
Isotype	Rabbit IgG
Reactivity	Human
Solubility	Flow Cyt 1/100
Synonyms	SLAM7 (19A, CD319, CRACC, CS1)
Usage	Research use only

Form	Powder
Purification	Purified from cell culture supernatant by affinity chromatography
Storage	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Applications	Flow Cyt, ELISA

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SKU	Supplier No.	Size	Your price	Quantity
BHA18100126	DME100010B	100 ug	$597		Add to Cart
BHA18100126	DME100010B	10 ug	$90		Add to Cart

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