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Home / Primary Antibodies / Monoclonal Antibodies

Biotin Anti-Human CD74 Antibody[LN2]

SKU : BHA10325053

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	E-AB-F1072B
Background	CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-kB activation, and IL-8 production.
Clonality	Monoclonal
Host	Mouse
Immunogen	0
Isotype	Mouse IgG1, kappa
Reactivity	Human

Clone No	LN2
Research Area	Cancer, Immunology

Buffer	PBS with 0.05% Proclin300, 1% BSA
Concentration	0.5 mg/mL
Storage	Store at 2~8°C. Do not freeze.

Applications	FCM

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA10325053	E-AB-F1072B	25?g	$53		Add to Cart
BHA10325053	E-AB-F1072B	100?g	$184		Add to Cart

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