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Home / Primary Antibodies / Monoclonal Antibodies

ATRX

SKU : BHA15100450

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Mfr.No.	AMB05-5M
Clonality	Monoclonal
Description	?-thalassemia/mental retardation X-linked (ATRX) is a transcriptional regulator and helicase that belongs to the SNF2 family of chromatin remodeling proteins. Together with its binding partner death-associated protein 6 (Daxx), ATRX acts as histone chaperone to deposit histone variant H3.3 at repetitive DNA sequences such as telomeric, pericentric, and ribosomal gene repeats. It involved in transcriptional regulation and chromatin remodeling. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Research studies indicate that the loss of ATRX protein occurs in numerous cancers, including pancreatic neuroendocrine tumors (PanNETs) and pediatric glioblastoma, where telomere maintenance occurs independently of telomerase
Host	Mouse
Isotype	Ig2a
Reactivity	Human
Species	Mouse

Clone No	D-5
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:50-100

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AMB05-5M	AMB05-5M	6 mL	$310		Add to Cart
AMB05-10M	AMB05-10M	100 tests - i6000	$582		Add to Cart
AXB05-50D	AXB05-50D	50 tests - Xmatrx	$327		Add to Cart
AXB05-YCD	AXB05-YCD	160 tests - Xmatrx	$795		Add to Cart
MUB05-UC	MUB05-UC	1ml Conc	$637		Add to Cart
MUB05-5UC	MUB05-5UC	0.5ml Conc	$446		Add to Cart

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