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Home / Primary Antibodies / Monoclonal Antibodies

APC Anti-Mouse CD272 Antibody[PK18.6]

SKU : BHA10324765

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	E-AB-F1024E
Background	CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and nave T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.
Clonality	Monoclonal
Host	Rat
Immunogen	0
Isotype	Rat IgG1, kappa
Reactivity	Mouse

Clone No	PK18.6
Research Area	Immunology

Buffer	PBS with 0.05% Proclin300, 1% BSA
Storage	Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Applications	FCM

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA10324765	E-AB-F1024E	20Tests	$40		Add to Cart
BHA10324765	E-AB-F1024E	50Tests	$65		Add to Cart
BHA10324765	E-AB-F1024E	100Tests	$100		Add to Cart
BHA10324765	E-AB-F1024E	200Tests	$160		Add to Cart

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