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Home / Primary Antibodies / Monoclonal Antibodies

Anti-WWOX Antibody Picoband® (monoclonal, 3D10)

SKU : BHA21002105

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Mfr.No.	M01223, M01223-10ug, M01223-Biotin, M01223-Cy3, M01223-Dylight488, M01223-Dylight550, M01223-Dylight594, M01223-FITC, M01223-HRP, M01223-APC, M01223-PE, M01223-iFluor647, M01223-carrier-free
Alternative Names	WW domain containing oxidoreductase
Background	WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. It spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alteative splicing results in multiple transcript variants.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-WWOX Antibody Picoband® (monoclonal, 3D10) catalog # M01223. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-m
Host	Mouse
Immunogen Region	E. coli-derived human WWOX recombinant protein (Position: M1-D245).
Isotype	Mouse IgG1
Molecular Weight	47 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1; WWOX; FOR; SDR41C1; WOX1
Tissue Specificity	Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9NZC7
Gene Id	51741
Gene Name	WWOX
Clone No	Clone: 3D10
Subcellular Location	Mitochondrion. Golgi apparatus. Nucleus. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. "Entrez Gene: WWOX WW domain containing oxidoreductase".<br /><br />2. Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM (May 2000). "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer". Cancer Res. 60 (8): 21405.<br /><br />3. Mahajan NP, Whang YE, Mohler JL, Earp HS (November 2005). "Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.". Cancer Res. 65 (22): 1051423.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002105-1	M01223	-	100 ug	$370		Add to Cart
BHA21002105-2	M01223-10ug	Sample	10 ug	$99		Add to Cart
BHA21002105-3	M01223-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002105-4	M01223-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002105-5	M01223-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002105-6	M01223-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002105-7	M01223-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002105-8	M01223-FITC	FITC	100 ug	$570		Add to Cart
BHA21002105-9	M01223-HRP	HRP	100 ug	$570		Add to Cart
BHA21002105-10	M01223-APC	APC	100 ug	$670		Add to Cart
BHA21002105-11	M01223-PE	PE	100 ug	$670		Add to Cart
BHA21002105-12	M01223-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002105-13	M01223-carrier-free	carrier-free	100 ug	$370		Add to Cart

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