This human monoclonal antibody recognizes human V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA), and neutralizes its interaction with VSIG3 (also called IGSF11). VISTA is also known as B7-H5 or VSIR (GenBank Accession No. NM_022153). VSIG3 is a ligand involved in cell adhesion as a VISTA binding partner. This neutralizing antibody has been functionally tested using the VSIG-3:VISTA (Biotinylated) Inhibitor Screening Assay Kit (BPS Bioscience #79782).
assay conditions: The functional activity of the antibody was measured using VSIG-3:VISTA (Biotinylated) Inhibitor Screening Assay Kit (BPS Bioscience #79782)
Formulation
8 mM phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl, 20% glycerol
Isotype
Human IgG1
Molecular Weight
~150 kDa
Specificity
The antibody recognizes a unique epitope on the surface of human VISTA protein. It has not been tested on other species