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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Topoisomerase II, Alpha (TOP2A)

SKU : BHA15100297

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BioGenex Laboratories

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Mfr.No.	AN823-5M
Clonality	Monoclonal
Description	DNA topoisomerase II alpha (Topo-II?) is an essential to maintain the topology of DNA, it up-regulated in different tumors. Topo II is maintains chromatin condensation and separation during mitosis. DNA topoisomerase II alpha levels are cell cycle regulated and the expression level increases between G2 to M phase after replication phase. DNA topoisomerase II alpha has been linked with maintenance of DNA integrity during cell proliferation and it may be the main isoform of Topo II involved mitotic processes. Topo II ? passes one strand of DNA through a reversible break in a second DNA strand, which catalyzes the topological isomerization of DNA during cell cycle. Due to its significance, Topo II ? overexpression is the target for many chemotherapeutic agents. The majority of anticancer drugs targeting Topo II? initiate apoptosis by stabilizing the reversible covalent complex formed between DNA and Topo II?
Host	Rabbit
Isotype	IgG
Reactivity	Human
Species	Rabbit

Clone No	EP93
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:50-100

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AN823-5M	AN823-5M	6 mL	$271		Add to Cart
AN823-10M	AN823-10M	100 tests - i6000	$484		Add to Cart
AY823-50D	AY823-50D	50 tests - Xmatrx	$285		Add to Cart
AY823-YCD	AY823-YCD	160 tests - Xmatrx	$769		Add to Cart
NU823-UC	NU823-UC	1ml Conc	$489		Add to Cart
NU823-5UC	NU823-5UC	0.5ml Conc	$339		Add to Cart

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