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Home / Primary Antibodies / Monoclonal Antibodies

Anti-TBP-1/PSMC3 Antibody Picoband® (monoclonal, 4D3)

SKU : BHA21003504

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Mfr.No.	M07208-2, M07208-2-10ug, M07208-2-Biotin, M07208-2-Cy3, M07208-2-Dylight488, M07208-2-Dylight550, M07208-2-Dylight594, M07208-2-FITC, M07208-2-HRP, M07208-2-APC, M07208-2-PE, M07208-2-iFluor647, M07208-2-carrier-free
Alternative Names	chaperonin containing TCP1 subunit 3
Background	26S protease regulatory subunit 6A, also known as 26S proteasome AAA-ATPase subunit Rpt5, is an enzyme that in humans is encoded by the PSMC3 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-TBP-1/PSMC3 Antibody Picoband® (monoclonal, 4D3) catalog # M07208-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vi
Host	Mouse
Immunogen Region	E.coli-derived human TBP-1/PSMC3 recombinant protein (Position: M1-A439).
Isotype	Mouse IgG2b
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	T-complex protein 1 subunit gamma; TCP-1-gamma; CCT-gamma; hTRiC5; CCT3; CCTG; TRIC5
Tissue Specificity	Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P17980
Gene Id	5702
Gene Name	PSMC3
Clone No	Clone: 4D3
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. Co, P. G., McDonald, E. R., III, Herman, J. G., El-Deiry, W. S. Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Nature Genet. 35: 229-237, 2003. 2. DeMartino, G. N., Proske, R. J., Moomaw, C. R., Strong, A. A., Song, X., Hisamatsu, H., Tanaka, K., Slaughter, C. A. Identification, purification, and characterization of a PA700-dependent activator of the proteasome. J. Biol. Chem. 271: 3112-3118, 1996. 3. Hoyle, J., Tan, K. H., Fisher, E. M. C. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). Hum. Genet. 99: 285-288, 1997

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003504-1	M07208-2	-	100 ug	$370		Add to Cart
BHA21003504-2	M07208-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003504-3	M07208-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003504-4	M07208-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003504-5	M07208-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003504-6	M07208-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003504-7	M07208-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003504-8	M07208-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003504-9	M07208-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003504-10	M07208-2-APC	APC	100 ug	$670		Add to Cart
BHA21003504-11	M07208-2-PE	PE	100 ug	$670		Add to Cart
BHA21003504-12	M07208-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003504-13	M07208-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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