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Home / Primary Antibodies / Monoclonal Antibodies

Anti-SMAD2 Antibody Picoband® (monoclonal, 3C4)

SKU : BHA21003215

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Mfr.No.	M00090-3, M00090-3-10ug, M00090-3-Biotin, M00090-3-Cy3, M00090-3-Dylight488, M00090-3-Dylight550, M00090-3-Dylight594, M00090-3-FITC, M00090-3-HRP, M00090-3-APC, M00090-3-PE, M00090-3-iFluor647, M00090-3-carrier-free
Alternative Names	high mobility group box 1
Background	Smad2 (Mothers against decapentaplegic homolog 2), also known as MADR2, MADH2, SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. Eppert et al. mapped the MADR2 gene close to DPC4 at 18q21, a region which is frequently deleted in colorectal cancers. Riggins et al. mapped the human MADH2 gene to 18q21. Nakao et al. refined the localization of the SMAD2 gene to 18q21.1, approximately 3 Mb proximal to DPC4, by fluorescence in situ hybridization. SMAD2 mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SMAD2 Antibody Picoband® (monoclonal, 3C4) catalog # M00090-3. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remod
Host	Mouse
Immunogen Region	E.coli-derived human SMAD2 recombinant protein (Position: E83-Q264).
Isotype	Mouse IgG1
Molecular Weight	55 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	High mobility group protein B1; High mobility group protein 1; HMG-1; HMGB1; HMG1
Tissue Specificity	Ubiquituous. Expressed in platelets.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q15796
Gene Id	4087
Gene Name	SMAD2
Clone No	Clone: 3C4
Subcellular Location	Nucleus. Endosome. Secreted. Cell membrane. Peripheral membrane protein. Extracellular side. Chromosome. Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Eppert, K., Scherer, S. W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L.-C., Bapat, B., Gallinger, S., Andrulis, I. L., Thomsen, G. H., Wrana, J. L., Attisano, L.MADR2 maps to 18q21 and encodes a TGF-beta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.Cell 86: 543-552, 1996.<br /><br />2. Nakao, A., Roijer, E., Imamura, T., Souchelnytskyi, S., Stenman, G., Heldin, C.-H., ten Dijke, P.Identification of Smad2, a human Mad-related protein in the transforming growth factor-beta signaling pathway.J. Biol. Chem. 272: 2896-2900, 1997.<br /><br />3. Riggins, G. J., Thiagalingam, S., Rozenblum, E., Weinstein, C. L., Ke, S. E., Hamilton, S. R., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., Vogelstein, B.Mad-related genes in the human.Nature Genet. 13: 347-349, 1996.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003215-1	M00090-3	-	100 ug	$370		Add to Cart
BHA21003215-2	M00090-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21003215-3	M00090-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003215-4	M00090-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003215-5	M00090-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003215-6	M00090-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003215-7	M00090-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003215-8	M00090-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21003215-9	M00090-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21003215-10	M00090-3-APC	APC	100 ug	$670		Add to Cart
BHA21003215-11	M00090-3-PE	PE	100 ug	$670		Add to Cart
BHA21003215-12	M00090-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003215-13	M00090-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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