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Home / Primary Antibodies / Monoclonal Antibodies

Anti-SHMT1 Antibody Picoband® (monoclonal, 9C7)

SKU : BHA21003233

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Mfr.No.	M02944, M02944-10ug, M02944-Biotin, M02944-Cy3, M02944-Dylight488, M02944-Dylight550, M02944-Dylight594, M02944-FITC, M02944-HRP, M02944-APC, M02944-PE, M02944-iFluor647, M02944-carrier-free
Alternative Names	high mobility group box 3
Background	This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alteative splicing results in multiple transcript variants.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SHMT1 Antibody Picoband® (monoclonal, 9C7) catalog # M02944. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Multifunctional protein with various roles in different cellular compartments,May act in a redox sensitive manner.Associates with chromatin and binds DNA with a preference to non- canonical DNA structures such as single-stranded DNA. Can bent DNA and enha
Host	Mouse
Immunogen Region	E.coli-derived human SHMT1 recombinant protein (Position: M1-S470).
Isotype	Mouse IgG1
Molecular Weight	53 kDa
Reactivity	Human, Mouse, Rat, Monkey
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	"chromosomal protein, Nonhistone, HMG4 antibody\|High mobility group (nonhistone chromosomal) protein 4 antibody\|High mobility group box 3 antibody\|High mobility group protein 2a antibody\|High mobility group protein 4 antibody\|High mobility group protein B3 antibody\|High mobility group protein HMG4 antibody\|HMG 4 antibody\|HMG-2a antibody\|HMG-4 antibody\|HMG2A antibody\|HMGB 3 antibody\|HMGB3 antibody\| HMGB3_HUMAN antibody\|MGC90319 antibody\|Non histone chromosomal protein antibody\|Nonhistone chromosomal protein HMG4 antibody"
Tissue Specificity	Expressed predominantly in placenta.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P34896
Gene Id	6470
Gene Name	SHMT1
Clone No	Clone: 9C7
Subcellular Location	Nucleus . Chromosome . Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5ug/ml, Mouse, Monkey, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Bye, P. C., Shipley, J. M., Chave, K. J., Sanders, P. G., Snell, K. Characterisation of a human serine hydroxymethyltransferase pseudogene and its localisation of 1p32.3-33. Hum. Genet. 97: 340-344, 1996.<br /><br />2. Elsea, S. H., Juyal, R. C., Jiralerspong, S., Finucane, B. M., Pandolfo, M., Greenberg, F., Baldini, A., Stover, P., Patel, P. I. Haploinsufficiency of cytosolic serine hydroxymethyltransferase in the Smith-Magenis syndrome. Am. J. Hum. Genet. 57: 1342-1350, 1995. <br /><br />3. Garrow, T. A., Brenner, A. A., Whitehead, V. M., Chen, X.-N., Duncan, R. G., Korenberg, J. R., Shane, B. Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization. J. Biol. Chem. 268: 11910-11916, 1993.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003233-1	M02944	-	100 ug	$370		Add to Cart
BHA21003233-2	M02944-10ug	Sample	10 ug	$99		Add to Cart
BHA21003233-3	M02944-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003233-4	M02944-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003233-5	M02944-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003233-6	M02944-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003233-7	M02944-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003233-8	M02944-FITC	FITC	100 ug	$570		Add to Cart
BHA21003233-9	M02944-HRP	HRP	100 ug	$570		Add to Cart
BHA21003233-10	M02944-APC	APC	100 ug	$670		Add to Cart
BHA21003233-11	M02944-PE	PE	100 ug	$670		Add to Cart
BHA21003233-12	M02944-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003233-13	M02944-carrier-free	carrier-free	100 ug	$370		Add to Cart

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