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Home / Primary Antibodies / Monoclonal Antibodies

Anti-RPA70 RPA1 Antibody Picoband® (monoclonal, 11H4)

SKU : BHA21002044

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Mfr.No.	M01317-2, M01317-2-10ug, M01317-2-Biotin, M01317-2-Cy3, M01317-2-Dylight488, M01317-2-Dylight550, M01317-2-Dylight594, M01317-2-FITC, M01317-2-HRP, M01317-2-APC, M01317-2-PE, M01317-2-iFluor647, M01317-2-carrier-free
Alternative Names	replication protein A1
Background	Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene. This gene is mapped to chromosome 17p13.3. Replication protein A (RPA) is a heterotrimeric single-strand DNA (ssDNA)-binding protein essential for DNA replication, repair, and recombination. It is composed of 70-kD (RPA1), 32-kD (RPA2), and 14-kD (RPA3) subunits. The RPA1 subunit is responsible for high-affinity ssDNA binding. The RPA complex was originally isolated as a factor essential for in vitro replication of the papovavirus SV40. It had been found that recombinant human RPA1, purified from bacteria, exhibited ssDNA-binding activity comparable to that of the complete RPA complex. RPA1 could substitute for the complete complex in stimulating the activity of DNA polymerase alpha-primase, but it could not substitute for the complete complex in SV40 DNA replication in vitro, suggesting an important functional role for the other subunits.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-RPA70 RPA1 Antibody Picoband® (monoclonal, 11H4) catalog # M01317-2. Tested in Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates diff
Host	Mouse
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human RPA70, different from the related mouse sequence by three amino acids.
Isotype	Mouse IgG2b
Molecular Weight	12 kDa
Reactivity	Human, Monkey, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Replication protein A 70 kDa DNA-binding subunit; RP-A p70; Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding protein; Replication protein A 70 kDa DNA-binding subunit, N-terminally processed; RPA1; REPA1; RPA70
Tissue Specificity	Expressed in lung fibroblasts (at protein level). Expressed in monocytes. Highly expressed in liver, also found in kidney and brain.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P27694
Gene Id	6117
Gene Name	RPA1
Clone No	Clone: 11H4
Subcellular Location	Nucleus

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. Erdile, L. F., Heyer, W.-D., Kolodner, R., Kelly, T. J. Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication. J. Biol. Chem. 266: 12090-12098, 1991. Note: Erratum: J. Biol. Chem. 268: 2268 only, 1993. <br /><br />2. Haring, S. J., Mason, A. C., Binz, S. K., Wold, M. S. Cellular functions of human RPA1: multiple roles of domains in replication, repair, and checkpoints. J. Biol. Chem. 283: 19095-19111, 2008. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002044-1	M01317-2	-	100 ug	$370		Add to Cart
BHA21002044-2	M01317-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002044-3	M01317-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002044-4	M01317-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002044-5	M01317-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002044-6	M01317-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002044-7	M01317-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002044-8	M01317-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002044-9	M01317-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002044-10	M01317-2-APC	APC	100 ug	$670		Add to Cart
BHA21002044-11	M01317-2-PE	PE	100 ug	$670		Add to Cart
BHA21002044-12	M01317-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002044-13	M01317-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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